Interactions between genetic background, insulin resistance and β-cell function
نویسندگان
چکیده
منابع مشابه
Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer.
BACKGROUND Obesity and diabetes mellitus are associated with an increased risk of pancreatic cancer. These associations may be secondary to consequences of peripheral insulin resistance, pancreatic β-cell dysfunction, or hyperglycemia itself. Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of peripheral insulin resistance, and the proinsul...
متن کاملCharacterization of β-cell function and insulin resistance in overweight Chinese adolescents with normal glucose tolerance
This study aimed to investigate the characteristics of insulin resistance and β-cell secretion in healthy adolescents. A total of 124 adolescents with normal glucose tolerance (NGT) were divided according to BMI into normal weight (n=31; control), overweight (n=52) and obese (n=41) groups. Oral glucose tolerance tests were performed, and blood glucose (G0, G30 and G120) and insulin (I0, I30 and...
متن کاملAdaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance
High-carbohydrate diets have been associated with β-cell strain, dyslipidemia, and endothelial dysfunction. We examined how β-cell and endothelial function adapt to carbohydrate overloading and the influence of insulin resistance. On sequential days in randomized order, nondiabetic subjects (classified as insulin-sensitive [IS] [n = 64] or insulin-resistant [IR] [n = 79] by euglycemic clamp) re...
متن کاملInfluence of Hyperinsulinemia and Insulin Resistance on In Vivo β-Cell Function
OBJECTIVE Recent work has shown that insulin stimulates its own secretion in insulin-sensitive humans, suggesting that insulin resistance in the β-cell could cause β-cell dysfunction. We have tested whether insulin exposure and insulin sensitivity modulate β-cell function in subjects with normal glucose tolerance (NGT) and whether they contribute to dysglycemia in impaired glucose regulation (I...
متن کاملβ-Cell dysfunction and insulin resistance in gestational glucose intolerance
Copyright © 2013 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 1226-3303 eISSN 2005-664...
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ژورنال
عنوان ژورنال: Diabetes, Obesity and Metabolism
سال: 2012
ISSN: 1462-8902
DOI: 10.1111/j.1463-1326.2012.01650.x